Francis Root Day was born in St. Joseph, Missouri, on August 16, 1859, the son of Charles Webster Day. Francis' family moved to Chicago when the American Civil War broke out in order to avoid the secessionist sentiments of Missouri. He attended public school and highschool there, then entered the University of Michigan for pre-medical training.

Dr. Day received his medical degree from Rush Medical College in 1883, and practiced medicine in Chicago during the following three years. After leaving Chicago, Dr. Day filled the position of surgeon aboard the "S.S. Australia," but decided in October 1887 to settle in Honolulu. There he took over the practice of Dr. George H. Martin, and soon numbered among his patients some of the city's most prominent citizens.

Dr. Day became very active in the Honolulu medical community and was soon appointed to the new Provisional Government's Board of Health, of which he later became president. He also held the position of Port Physician for four years, eventually turning over that responsibility to the federal authorities at the time of the annexation of Hawaii.

After going on a trip around the world with his wife, Dr. Day returned to Honolulu and his medical practice. He and Dr. C.B. Wood established a partnership that ended only with Dr. Day's death in Honolulu in 1906.

Walter H.O. Hoffmann was born in Berlin, Germany in 1872, and received his medical degree from Jean Medical School in 1897. He arrived in Honolulu, Hawaii a year later, and was soon practicing medicine there, identifying patients with leprosy at the Kalihi Receiving Station. During his time in Honolulu, Dr. Hoffmann experimented on twelve patients with chaulmoogra oil, a treatment which became standard use in leprosy cases for many years.

Dr. Hoffmann distinguished himself during the bubonic epidemic which swept the Islands in the late nineteenth and early twentieth centuries by performing autopsies on the bodies of those suspected to have died of the plague. He confirmed 60 such cases.

In the mid-1910s, Dr. Hoffmann settled in Chicago and went back to academics, attending Rush Medical College there, from which he graduated in 1915. He established a practice in that city, specializing in pediatrics. He also was on the staff of two Chicago hospitals, and a member of the Chicago Pediatric Society.

James Robert Judd was a native of Honolulu, born in 1876. He was the grandson of medical missionary G.P. Judd, an imposing figure in the history of the Hawaiian Islands. James R. Judd received his early education locally, from Oahu College, which is now Punahou. He received his medical degree from Columbia University in 1901. After an internship in New York and further study abroad, Dr. Judd returned to the Islands to practice medicine in 1903.

Dr. Judd served in both the Spanish-American War and World War I, filling the positions of surgical assistant and chief surgeon. For his medical services in France during the First World War, Dr. Judd was awarded the Legion of Honor decoration in 1921. He returned to Hawaii after the war and resumed his private practice, in which he employed many new surgical techniques. At the outbreak of WWII, Dr. Judd cared for the wounded who flowed into Queen's Hospital when the American bases on Oahu were attacked.

George Francis Straub was christened Georg Franz Straub in Edenkoben, Bavaria, Germany, in March 1879. He received his medical degree in 1903 from the University of Heidelberg, and left Germany that same year. Before arriving in Hawaii on the last day of 1907, Dr. Straub stopped briefly in London and New York.

Upon his arrival in Honolulu, Dr. Straub opened an office and was soon practicing medicine as well as being active in the medical community. Within a year of his arrival, Dr. Straub testified as an expert on epilepsy and was named one of the staff physicians at the Queen's Hospital. By 1920, his medical practice had expanded to the extent that he took on five partners: Dr. Guy Milnor (obstetrics), Dr. Arthur Jackson (internal medicine), Dr. Eric Fennel (pathology), and Dr. Howard Clark (eye, ear and nose). Together the five doctors became partners in The Clinic in January 1921, and in 1955, the name of the group was changed to the Straub Clinic.

Although Dr. Straub retired from medical practice in 1933, he returned to medicine briefly during the war years of the Second World War, when he practiced again at The Clinic from 1942-1945.